Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process el 70 0.06 0.966 0.618 0.247
biological_process ka 70 0.0 0.679 0.078 0.166
biological_process rf 70 0.0 0.718 0.081 0.166
cellular_component ct 4 0.0 0.11 0.032 0.046
cellular_component el 4 0.0 0.738 0.328 0.332
cellular_component ka 4 0.002 0.145 0.043 0.059
cellular_component rf 4 0.0 0.11 0.032 0.045
disease ct 24 0.001 0.863 0.129 0.235
disease el 24 0.005 0.806 0.196 0.245
disease ka 24 0.0 0.853 0.132 0.245
disease rf 24 0.001 0.863 0.129 0.236
genetic_interaction el 63 0.0 1.0 0.412 0.332
genetic_interaction ka 63 0.0 0.992 0.419 0.33
genetic_interaction rf 63 0.0 1.0 0.418 0.334
molecular_function ct 7 0.0 0.744 0.161 0.272
molecular_function el 7 0.009 0.744 0.489 0.214
molecular_function ka 7 0.0 0.765 0.159 0.275
molecular_function rf 7 0.0 0.744 0.161 0.272
pathway ct 30 0.001 0.996 0.073 0.181
pathway el 30 0.001 0.207 0.03 0.053
pathway ka 30 0.001 0.849 0.16 0.256
pathway rf 30 0.001 0.176 0.033 0.049
phenotype ct 23 0.0 0.848 0.196 0.274
phenotype el 23 0.033 0.837 0.439 0.189
phenotype ka 23 0.0 0.942 0.224 0.303
phenotype rf 23 0.0 0.876 0.197 0.277
protein_interaction ct 73 0.0 0.741 0.038 0.125
protein_interaction el 73 0.0 0.779 0.039 0.132
protein_interaction ka 73 0.0 0.969 0.184 0.294
protein_interaction rf 73 0.0 0.74 0.037 0.124

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 73 0.0 0.8 0.102 0.181
integration_mean_by_presence el 73 0.0 0.889 0.057 0.145
integration_mean_by_presence ka 73 0.0 0.556 0.051 0.117
integration_mean_by_presence rf 73 0.0 0.508 0.031 0.084
mean ct 73 0.0 0.581 0.091 0.156
mean el 73 0.0 0.496 0.054 0.119
mean ka 73 0.0 0.542 0.049 0.111
mean rf 73 0.0 0.518 0.042 0.095

CDF plots of non integrated kernels

CDF plots of integrated kernels